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Sunghoon Kim Selected Research

Leucine (L-Leucine)

1/2022O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.
10/2020Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.
1/2018Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
11/2016Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors.

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Sunghoon Kim Research Topics

Disease

123Neoplasms (Cancer)
04/2024 - 03/2002
61Ovarian Neoplasms (Ovarian Cancer)
01/2024 - 02/2009
27Uterine Cervical Neoplasms (Cancer of the Cervix)
01/2023 - 12/2008
18Neoplasm Metastasis (Metastasis)
11/2023 - 03/2008
17Ovarian Epithelial Carcinoma
04/2024 - 01/2008
15Inflammation (Inflammations)
01/2023 - 09/2002
13Infections
12/2023 - 08/2002
13Postoperative Pain
12/2023 - 12/2008
13Carcinogenesis
11/2022 - 02/2004
11Lung Neoplasms (Lung Cancer)
12/2023 - 04/2006
11Endometrial Neoplasms (Endometrial Cancer)
12/2023 - 06/2013
10Pain (Aches)
12/2023 - 11/2002
10Wounds and Injuries (Trauma)
11/2023 - 02/2005
9Colonic Neoplasms (Colon Cancer)
02/2020 - 10/2002
8Carcinoma (Carcinomatosis)
01/2021 - 05/2008
6Breast Neoplasms (Breast Cancer)
04/2024 - 02/2009
6Disease Progression
12/2023 - 01/2007
6Starvation
01/2022 - 10/2006
5Residual Neoplasm
12/2023 - 01/2008
5Colorectal Neoplasms (Colorectal Cancer)
02/2020 - 10/2002
5Lymphatic Metastasis
11/2019 - 04/2014
5Hemorrhage
01/2017 - 10/2007
5Neuroblastoma
08/2004 - 05/2002
4Fibrosis (Cirrhosis)
10/2023 - 01/2018
4Adenocarcinoma
01/2021 - 01/2010
3Pancreatic Neoplasms (Pancreatic Cancer)
11/2023 - 08/2002
3Papillomavirus Infections
11/2021 - 01/2007
3Uterine Cervical Dysplasia
11/2021 - 09/2008
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2019 - 09/2017
3Sarcoma (Soft Tissue Sarcoma)
01/2019 - 01/2016
2Sepsis (Septicemia)
02/2024 - 12/2023

Drug/Important Bio-Agent (IBA)

54Proteins (Proteins, Gene)FDA Link
04/2024 - 05/2002
20Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA
11/2022 - 06/2007
18Biomarkers (Surrogate Marker)IBA
01/2024 - 09/2008
15Transfer RNA (tRNA)IBA
01/2023 - 09/2002
15Lysine-tRNA LigaseIBA
06/2021 - 08/2004
11PlatinumIBA
01/2024 - 06/2010
11CytokinesIBA
12/2023 - 02/2005
11Ligases (Synthetase)IBA
01/2022 - 08/2008
11Paclitaxel (Taxol)FDA LinkGeneric
06/2020 - 04/2006
10Messenger RNA (mRNA)IBA
06/2022 - 05/2002
10EnzymesIBA
11/2020 - 09/2002
9Methionine-tRNA LigaseIBA
11/2023 - 08/2004
8AntigensIBA
04/2024 - 07/2010
8DNA (Deoxyribonucleic Acid)IBA
01/2022 - 10/2002
7Hemoglobins (Hemoglobin)IBA
01/2023 - 12/2008
7Carboplatin (JM8)FDA LinkGeneric
03/2020 - 01/2013
7Cisplatin (Platino)FDA LinkGeneric
01/2019 - 03/2010
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2010 - 08/2002
6Tryptophan-tRNA LigaseIBA
02/2024 - 10/2016
6Mechanistic Target of Rapamycin Complex 1IBA
01/2022 - 11/2016
5durvalumabIBA
01/2024 - 11/2019
5Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2024 - 03/2020
5LigandsIBA
12/2023 - 08/2002
5B7-H1 AntigenIBA
11/2023 - 11/2019
5Transcription Factors (Transcription Factor)IBA
10/2017 - 10/2002
5Laminin ReceptorsIBA
01/2017 - 10/2012
4Leucine (L-Leucine)FDA Link
01/2022 - 11/2016
4Glycine-tRNA LigaseIBA
01/2022 - 03/2012
4Amino AcidsFDA Link
01/2022 - 10/2016
4Glucose (Dextrose)FDA LinkGeneric
01/2022 - 10/2006
4AntibodiesIBA
01/2020 - 03/2010
4RNA (Ribonucleic Acid)IBA
07/2019 - 02/2015
4MicroRNAs (MicroRNA)IBA
01/2019 - 05/2008
4Phosphotransferases (Kinase)IBA
05/2015 - 05/2008
4Small Interfering RNA (siRNA)IBA
04/2014 - 06/2012
3tremelimumabIBA
01/2024 - 11/2019
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2023 - 02/2015
3glutamyl-prolyl-tRNA synthetaseIBA
01/2023 - 11/2016
3Cadherins (E-Cadherin)IBA
01/2022 - 03/2012
3Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
04/2021 - 11/2018
3NF-kappa B (NF-kB)IBA
01/2021 - 08/2002
3Antiviral Agents (Antivirals)IBA
01/2019 - 11/2016
3Peptides (Polypeptides)IBA
01/2019 - 08/2014
3GelsIBA
11/2018 - 08/2015
3Laminin (Merosin)IBA
11/2018 - 01/2014
3Caspase 8 (Caspase-8)IBA
05/2018 - 04/2004
3AutoantibodiesIBA
01/2017 - 06/2010
3Sirolimus (Rapamycin)FDA Link
01/2017 - 01/2016
3CollagenIBA
02/2016 - 02/2005
2olaparibIBA
12/2023 - 10/2023
2cediranib (AZD2171)IBA
12/2023 - 10/2023

Therapy/Procedure

30Therapeutics
01/2024 - 05/2002
23Neoadjuvant Therapy
11/2023 - 01/2017
22Drug Therapy (Chemotherapy)
01/2024 - 01/2007
19Hysterectomy
01/2021 - 10/2007
12Length of Stay
01/2023 - 10/2011
10Lymph Node Excision (Lymph Node Dissection)
11/2023 - 12/2008
9Immunotherapy
01/2023 - 01/2006
8Laparotomy
12/2023 - 09/2007
8Radiotherapy
09/2016 - 03/2010
6Adjuvant Chemotherapy
11/2019 - 05/2011
5Minimally Invasive Surgical Procedures
01/2021 - 03/2012
4Precision Medicine
02/2024 - 01/2020
4Hyperthermic Intraperitoneal Chemotherapy
12/2023 - 01/2019
4Operative Surgical Procedures
01/2021 - 06/2011
4Dilatation and Curettage
07/2020 - 10/2007
3Cytoreduction Surgical Procedures
12/2023 - 08/2011
3Surgical Instruments (Clip)
02/2013 - 07/2010
3Surgical Gloves (Surgical Glove)
02/2013 - 07/2010